All chapters have access to the six core professions¡ªWarrior, Ranger, Elementalist, Necromancer, Mesmer, and Monk. A player must own Factions to create an Assassin or Ritualist, while only Nightfall owners can create a Dervish or a Paragon about Guild Wars Gold.

As stated above in PvP Importance, only Nightfall offers the use of customizable henchmen called Heroes. All chapters allow you to use AI-controlled ¡°henchmen¡± to fill out your group; but Heroes allow you to manually use their skills and edit their builds and attributes, as well as individually assign those positions on the map about Guild Wars Gold. Heroes are extremely useful for PvE, and even have their own PvP arenas called Hero Battles, which allow two human players to fight each other using teams of four: one human player and his or her three Heroes.

Each chapters setting has been inspired by real world geography and cultures. Prophecies were designed around the traditional medieval setting in the style of King Arthur legends. Factions have an East Asian theme about Guild Wars Gold, while Nightfall is a mix of North Africa, Egypt, Middle East, and Greek elements about Guild Wars Gold.

While there is some debate on whether Prophecies or Nightfall has the better storyline, it is generally accepted that the Factions storyline is inferior to the other chapters. The games lengths can be roughly measured by the number of missions they contain. While quests in Guild Wars send your party out into the explorable world to perform tasks, missions send your party to a specific zone, where the group must achieve an objective under certain conditions. After a mission is completed, players will either find themselves in the next mission staging area, or else they will receive quests that will lead them to the next mission.